Many doctors are choosing a better-safe-than-sorry approach to heading off heart trouble in very elderly patients. Inexpensive statin drugs are given to millions of people to reduce cholesterol, even many who do not show signs of heart disease.
But a recent study has found that seniors with no history of heart trouble are now four times more likely to get those drugs than they were in 1999. Here’s the catch: For patients of that age, there is little research showing statins’ preventive heart benefits outweigh possible risks, which can include muscle pain and the onset of diabetes.
There have only been a handful of studies that included the over-79 population, according to a review in the American Journal of Cardiology in 2012. With the average life expectancy at 76 for men and 81 for women in the U.S., drug companies haven’t funded such studies in people above 79. There have been many studies involving younger people. Statins have been shown to reduce the risks of a heart attack or stroke in patients who have had one and possibly prevent an episode in people with high cholesterol who haven’t.
The drugs, which include the well-known brands Lipitor and Crestor as well as generics, have been on the market for almost 30 years. Arta Bakshandeh, a senior medical officer with Alignment Healthcare, a company that advises Medicare insurance plans, sums up the dilemma for health plans and doctors with elderly patients. “With health reform there is a push to have primary prevention … if you can prevent [beneficiaries] from having a heart attack that will cost way more than the $30,000 for a statin over the lifetime, we should focus on primary prevention,” he said.
This KHN story also ran in USA Today.
“But if we’re overprescribing and not taking into account all the drugs patients are on, that is going to land people in the hospital as well. It’s a fine balance.”The rate of statin use among octogenarians and beyond who don’t have a history of heart attack, stroke, coronary heart disease or vascular heart disease increased four times from 1999 through 2012, according to two researchers from Ohio State University and the University of Alberta in Edmonton, Canada. Their research letter was published in the Journal of the American Medical Association Internal Medicine in August.
Despite the lack of evidence to guide the use of statins in this population, “the very elderly have the highest rate of statin use in the United States,” they said, citing past studies. Concerns about statins’ effects in those older than 79 are being raised as some cardiologists question whether statins are overprescribed even among some younger people.
Guidelines published by the American Heart Association and the American College of Cardiology in 2013 recommended statins as a preventive measure for people with high cholesterol but no overt heart disease if their 10-year risk of suffering a heart attack or stroke is 7.5% or higher.